Lipinski's Rule of Five Guide, Meaning , Facts, Information and Description
Christopher A. Lipinski formulated a so-called rule of 5 as criteria for oral bioavailability. (See ADME) These four "rules" are common characteristics found in most drugs available today. The rule of 5 derives its name from the fact that the relevant cutoffs are all multiples of 5:
- not more than 5 hydrogen bond donors
- no more the 10 hydrogen bond acceptors (notably N and O)
- molecular weight under 500
- LogP under 5
References
- CA Lipinski, Adv. Drug Del. Rev. 1997, 23, 3
External links
- http://www.molinspiration.com/cgi-bin/properties (interactive Rule of Five calculator)
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