Hyperparathyroidism Guide, Meaning , Facts, Information and Description
In medicine (endocrinology), hyperparathyroidism is overactivity of the parathyroid glands and excess production of parathyroid hormone (PTH). Consequences are weakness of bone tissue (predisposing for fracture) and hypercalcemia (high calcium levels).Primary hyperparathyroidism is usually the result of a benign parathyroid tumor (adenoma) that loses its sensitivity to circulating calcium levels. Usually, only one of the four parathyroid glands is affected.
In chronic renal failure secondary hyperparathyroidism can result. Its result on bone metabolism is renal osteodystrophy.
Signs, symptoms, diagnosis, and treatment
In short-lived hyperparathyroidism, hypercalcemia might be the only sign, sometimes producing such symptoms as nausea, vomiting, lethargy, depression, muscular weakness and an altered mental state.
Diagnostic workup for hypercalcemia often includes testing the PTH levels. Ultrasound of the neck area may reveal enlarged glands. Occasionally, scintigraphy with MIBI is necessary to identify adenomas or hyperplastic parathyroids.
The only current method of treatment is surgery (although newer surgery techniques are much less invasive and much more effective than older techniques). The procedure is called parathyroidectomy. Usually, the surgery will only involve one of the glands, and so a successful surgery will allow the parathyroids to go back to correctly regulating blood calcium levels.
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