Domperidone Guide, Meaning , Facts, Information and Description
Domperidone (Motillium®) is an antidopaminergic drug used orally or intravenously, generally to suppress nausea and vomiting. As decreased dopamine levels also stimulate levels prolactin, a hormone neccesary for lactation in humans, it has been used to stimulate lactation.
Use for gastrointestinal problems
Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting. It cannot be used in patients with Parkinson's disease due to its interference with dopamine signalling.
Use for lactation
Although it has never been officially approved for use in the United States, domperidone is widely purchased from pharmacies in other countries. It has also been approved in certain countries for gastric problems, and in many of these same countries, carries warnings that it should nto be used by nursing mothers.
In June, the United States' main regulation agency, the Food and Drug Administration (FDA) issued a letter warning women not to take domperidone, citing unknown risks to parents and infants, and warned pharmaciecs that domestic sale was illegal, and that import shipments from other countries would be searched and seized. Individual incidents of problems with the drug include cardiac arrest and arrythmia, complications with other medications, as well as complications with improper intravenous use.
It has been widely speculated that this action by the FDA is related to increasing drug importation from countries such as Canada. However, organisations such as the American Association of Pediatrics have endorsed the FDA action.
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